CRISPR INTERFERENCE OF A CLONALLY VARIANT GC-RICH NONCODING RNA FAMILY LEADS TO GENERAL REPRESSION OF VAR GENES IN PLASMODIUM FALCIPARUM

CRISPR Interference of a Clonally Variant GC-Rich Noncoding RNA Family Leads to General Repression of var Genes in Plasmodium falciparum

ABSTRACT The human malaria parasite Plasmodium falciparum uses mutually exclusive expression of the PfEMP1-encoding var gene family to evade the host immune system.Despite progress in the molecular understanding of the default silencing mechanism, the activation mechanism of the uniquely expressed var member remains elusive.A GC-rich noncoding RNA

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Structure, Mechanical Properties and Friction Characteristics of the Al-Mg-Sc Alloy Modified by Friction Stir Processing with the Mo Powder Addition

In this study, samples of Al-Mg-Sc alloy were investigated after friction stir processing with the addition of Mo powder.Holes were drilled into 5 mm-thick aluminum alloy sheets into which Mo powder was added at percentages of 5, 10, and 15 wt%.The workpieces with different powder contents were then subjected to four passes of friction stir process

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